منابع مشابه
Methotrexate-related pulmonary complications in rheumatoid arthritis.
Methotrexate (MTX) was described as a drug in 1946' and first used in the treatment of human disease (childhood leukaemia) in 1948.2 Successful MTX treatment for rheumatoid arthritis (RA) and psoriasis was reported in 1951,3 although the interest in this drug at that time was probably overshadowed by the impressive results of cortico-steroid treatment until approximately 1980. MTX was approved ...
متن کاملMethotrexate-induced pulmonary lymphoma.
Methotrexate has proven to be effective in treating rheumatoid arthritis (RA), and is believed to be nononcogenic in the low weekly dose typically employed in the patients with RA. We report, however, a patient with RA in whom a rapidly enlarging diffuse large B-cell lymphoma developed in the left upper lung after weekly treatment with methotrexate for 5 years. The patient had a positive serum ...
متن کاملTreatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab
BACKGROUND Treatment of rheumatoid arthritis (RA) with a combination of methotrexate (MTX)+adalimumab (ADA) is more effective than ADA monotherapy. We assessed the toxicity of different doses of MTX and treatment efficacy of ADA+MTX in two trials. METHODS Data originated from CONCERTO, in patients with early RA initiating ADA+ 2.5, 5, 10 or 20 mg/week MTX for 26 weeks; and MUSICA, in patients...
متن کاملPotentiation of Methotrexate Toxicity by Dipyridamole1
Dipyridamole, an inhibitor of facilitated transport systems for purines and pyrimidines, was shown to enhance the toxicity of methotrexate (MTX) against cells in culture and in mice. Under certain incubation conditions, the availability of preformed pu rines and pyrimidines in undialyzed serum appeared to render Chinese hamster ovary cells insensitive to MTX. Addition to the culture of nontoxic...
متن کاملA case of acute methotrexate toxicity.
Dear Editor, Methotrexate (MTX) is an anti-metabolite frequently used in the treatment of psoriasis, rheumatoid arthritis and cancer. Long-term use of methotrexate is associated with hepatic and pulmonary toxicity. Acute methotrexate toxicity may present with extensive cutaneous ulceration, myelosuppression and gastrointestinal symptoms. It is important to recognise this as the drug must be dis...
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ژورنال
عنوان ژورنال: Respiratory Case Reports
سال: 2016
ISSN: 2147-2475
DOI: 10.5505/respircase.2016.66487